Vascular diseases are the number 1 cause of death globally.
18.6 Million deaths due to CVD in 2019 & 50% increase from 1990.
Disease prevalence is expected to increase as a result of the aging population.
In the US alone, cost of CVD between 2016 - 2017 was
364,4 Billion $
216 Billion $ direct cost &
147,4 Billion $
in lost productivity/mortality
Current methods for stratifying Vascular Diseases are flawed.
Tradition risk assessment does not consider vessel health & function.
Biomarkers, arterial stiffness, and calcification are all non-specific and serve only as indicators of vascular risk.
Exposure to ionizing radiation is a risk not only to patients. Staff working in the Cath lab are exposed to significant levels during live fluoroscopy.
Iodinated contrast agents are potentially allergenic, and carry a significant risk of nephrotoxicity in patients with co-morbidities.
" I'm often called to the Cath lab to stabilize a patient in renal decline, then I have to send them to rescue dialysis to clear out the (contrast) dye" - An emergency physician from California.
In patients who are at risk for kidney failure and who already have borderline kidney function, administering donated contrast material used in CT & CTA, could potentially further damage kidney function.